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Pancreatic Polypeptide, rat
CAS No. 90419-12-8
Pancreatic Polypeptide, rat( Rat pancreatic polypeptide )
Catalog No. M29743 CAS No. 90419-12-8
Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cells of the islets of Langerhans.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NamePancreatic Polypeptide, rat
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NoteResearch use only, not for human use.
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Brief DescriptionPancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cells of the islets of Langerhans.
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DescriptionPancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cells of the islets of Langerhans.(In Vitro):Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca2+)i levels in BRIN BD11 cells at 1 μM.(In Vivo):Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice.
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In VitroPancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca2+)i levels in BRIN BD11 cells at 1 μM.
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In VivoPancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice.
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SynonymsRat pancreatic polypeptide
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PathwayOthers
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TargetOther Targets
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RecptorNPYR4
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Research Area——
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Indication——
Chemical Information
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CAS Number90419-12-8
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Formula Weight4398.87
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Molecular FormulaC195H298N58O57S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameSequence:Ala-Pro-Leu-Glu-Pro-Met-Tyr-Pro-Gly-Asp-Tyr-Ala-Thr-His-Glu-Gln-Arg-Ala-Gln-Tyr-Glu-Thr-Gln-Leu-Arg-Arg-Tyr-Ile-Asn-Thr-Leu-Thr-Arg-Pro-Arg-Tyr-NH2
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Khan D, et al. Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. Biochim Biophys Acta. 2017 Apr;1861(4):749-758.
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